Whilst it is uncertain whether PEG contained in mRNA vaccines may trigger anaphylaxis, additional precautions are required prior to administration. It is also a commonly used ingredient of other medications, hand sanitisers, cosmetics, bathroom products and colonoscopy preparation products, routinely used within Australia. PEG is an ingredient contained in mRNA COVID-19 vaccines (Comirnaty (Pfizer) and Spikevax (Moderna)). SAEFVIC staff may direct the report to an immunisation specialist or alternatively to a vaccine allergy specialist within the VicSIS network (a network of specialist immunisation clinics in Victoria), as appropriate.Īllergy to components of COVID-19 vaccines Polyethylene Glycol (PEG) Most of these cases (89%) occurred within 30 minutes of vaccination and 26% had a history of prior anaphylaxis.Ī confirmed vaccine allergy usually requires a specialist consultation with a vaccine allergy specialist, often with specific testing or a vaccine challenge under supervision.Īll COVID-19 immunisation hypersensitivity/allergic reactions should be reported to your state’s vaccine safety reporting service. Data from the US has shown that Spikevax (Moderna) has a rate of anaphylaxis with approximately 2.5 cases per million. Anaphylaxis following Comirnaty (Pfizer), whilst still extremely rare, occurs at a slightly higher rate of approximately 4.7 cases per million doses. Post-licensure surveillance of COVID-19 vaccines show anaphylaxis following administration of Vaxzevria (AstraZeneca) occurring at similar rates to routine vaccines. For further information on diagnosing hypersensitivity reactions and anaphylaxis please refer to Guidance for differentiating anaphylaxis and acute stress response for vaccine providers. Suspected hypersensitivity reactions, particularly non-urticarial skin rashes following immunisation, are common, however true vaccine allergy, where a person is contraindicated from being immunised with the same vaccine in the future, is rare (in most studies reported as less than 1 case per million doses).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |